O HPV como fator prevalente para indução do câncer de pênis

Abstract

Cancer is an infortuno in public health, given the intense incidence and cause of early mortality between the sexes, however, accentuated for the male public worldwide and nationally and this is associated with the high incidence of human papillomavirus (HPV) infection that holds high-risk classes of oncogenicdrugs, which are responsible for the development of lesions such as: cervical cancer; head and neck cancers; and anogenital cancers that includes Penile Cancer (PC). Furthermore, the other risk factors such as smoking, age of first relationship, number of partners, circumcision, socioeconomic aspects and HPV are extremely important. On the latter noted that there are two routes of induction, whether or not related to HPV. To this detriment, this research aims to analyze how HPV is a potential agent for the carcinogenesis of PC, and the contribution of other risk factors. For this, it is necessary to identify oncogenic HPV's, in addition to the analysis of the epidemiological profile, with national and regional focus; and demonstrate the prevalence of risk factors in order to identify their interference in the development of PC. The objectives of this research were achieved through bibliographic review and data collection and clinical trials identified through databases such as PubMed, MEDLINE, Lilacs and SciELO. Given the data collected, most studies in the area found a positive relationship between HPV and PC and their induction potential, especially in Brazil, Maranhão and the most recurrent types are HPV16 and HPV18 due to the hpv infection index, high prevalence of risk factors and heterogeny vaccination coverage. Having said that, it is concluded that HPV is a factor associated with the development of PC through pathophysiological and prevalent means, thus being indispensable for PC induction.