Análise da utilização da técnica de CRISPR-CAS9 para tratamento do câncer de pulmão: uma revisão integrativa

Abstract

The CRISPR-Cas9 technique was discovered in bacteria acting as an adaptive immune system, further research analyzed the possibility of using this system as a gene editing tool, so this method proves to be quite effective due to its ability to punctually edit genes. Thus, new studies were developed and their application was expanded to different sectors of medicine, one of them being the treatment of lung cancer. Thus, the objective of this work was to analyze the applications of the CRISPR-Cas9 system in the treatment of lung cancer. For this, a bibliographic search was carried out in Scielo, PubMed, Google Academic databases, as well as data from government agencies, using articles in Portuguese, English and Spanish that contemplated the theme and the proposed objectives. Research has shown a great potential of the technique for the treatment of lung cancer, which can be used to reduce the tumor or to improve the immune system in the fight against lung cancer, however further research is required in order to ensure the safety of the submitted patient a therapy.